Parkinson's disease

Parkinson’s disease is a progressive condition that involves a gradual loss of nerve cells in a finite area of the brain, leading to problems with movement control and other non-movement-related symptoms.

Parkinson’s disease is a long-term and progressive brain disease that most commonly affects those over the age of 60.1 People with Parkinson’s disease have difficulty controlling their body movements, and symptoms become worse as the condition progresses. Ultimately, Parkinson’s disease impairs the patient’s ability to function in daily life situations.

The symptoms of Parkinson’s disease result from a loss of nerve cells in the brain that affect movement control, as well as other areas, such as mood, sleep and thought. The exact cause of the nerve cell loss is not known, but it is believed to involve a combination of genetic, environmental and ageing factors.2

Symptoms

Classic symptoms of Parkinson’s disease – so-called ‘motor’ (movement-related) symptoms – include tremor, slowness of movement, muscle stiffness, and balance problems. In addition, non-motor symptoms are also common, for example, depression, dementia, pain, sleep problems and dysfunction in the body’s autonomic systems (digestion, blood pressure, etc.). All of these add considerably to the disease burden.

Parkinson’s disease is a progressive disorder and, over time, new symptoms appear and existing symptoms slowly become more severe. However, it is not a terminal illness – people can live for some 15 to 25 years from the point of diagnosis – which makes it a long-term (chronic) condition.3

Statistics

Parkinson’s disease is one of the most common neurological (nerve cell) disorders. It affected approximately 5.2 million men and women worldwide in 2004,with 4 to 20 new cases reported per 100,000 people per year. 4

Parkinson’s disease usually develops in people in their late 50s and early 60s,1 though rarer forms of the disease can develop before the age of 40.5 One study of five European countries found that 1.6% of the population aged 65 or over had Parkinson’s disease.6

Because the risk of developing Parkinson’s disease increases with age, the fact that more people are now living into old age means that the overall number of people with Parkinson’s disease is also rising.-7


Seeking diagnosis and care

At present, there is no cure for Parkinson’s disease, but once a diagnosis has been made by a medical professional, symptoms can be treated effectively in most cases. The aim of treatment is to control and relieve symptoms, so that people can continue to function and enjoy a reasonable quality of life for as long as possible.

Treatment for Parkinson’s disease normally involves drug therapy and, in some cases, surgery. In addition to this, physical exercise, diet, complementary therapies, emotional support and strong relationships all play important roles. Understanding Parkinson’s disease, relating to the new situation in life, and learning to accept new goals and challenges, are almost as important as practical management of the disease.

A person with Parkinson’s disease should not be afraid to ask for help, and it is important to receive expert medical advice.

 

References

  1. Weintraub D, Comella CL, Horn S. Parkinson's disease-Part 1: Pathophysiology, symptoms, burden, diagnosis, and assessment. Am J Manag Care. 2008; 14(2 Suppl):S40-8.
  2. Schapira AHV The management of Parkinson’s disease - what is new? Eur J Neurol 2011;18(Suppl 1):1-2.
  3. Poewe W, Mahlknecht The clinical progression of Parkinson's disease. Park and Rel Dis 2009;15(Suppl 4):S28-S32.
  4. de Lau LML, Breteler Monique MB. Epidemiology of Parkinson's disease. Lancet Neurology, 2006;5(6):525-535.
  5. Grimes DA. Parkinson’s disease: a guide to treatments, therapies and controlling symptoms. London: Constable & Robinson Ltd, 2004.
  6. de Rijk MC, Tzourio C, Breteler MM, et al. Prevalence of parkinsonism and Parkinson’s disease in Europe: the EUROPARKINSON Collaborative Study. European Community Concerted Action on the Epidemiology of Parkinson’s disease. J Neurol Neurosurg Psychiatry 1997; 62(1):10–15.
  7. Dorsey ER, Constantinescu R, Thompson JP, Biglan KM, Holloway RG, Kieburtz K, Marshall FJ, Ravina BM, Schifitto G, Siderowf A, Tanner CM. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030 Neurology 2007;68(5):384-386.
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