The following research papers and other scientific publications were co-authored by members of the Lundbeck staff from 2000 to date.

Publication title Author Source Drug Year
Is oral absorption of vigabatrin carrier-mediated? Nohr MK, Juul RV, Thale ZI, Holm R, Kreilgaard M, Nielsen CU European Journal of Pharmaceutical Sciences 2015;69:10-18 Vigabarin 2015 View abstract
Evaluation of the use of Göttingen minipigs to predict food effects on the oral absorption of drugs in humans Christiansen ML, Müllertz A, Garmer M, Kristensen J, Jacobsen J, Abrahamsson B, Holm R Journal of Pharmaceutical Sciences 2015;104(1):135-143 - 2015 View abstract
Population dose-response analysis of daily seizure count following vigabatrin therapy in adult and pediatric patients with refractory complex partial seizures Nielsen JC, Hutmacher MM, Wesche DL, Tolbert D, Patel M, Kowalski KG Journal of Clinical Pharmacology 2015;55(1):81-92 Vigabatrin 2015 View abstract
Lipophilic prodrugs of apomorphine I: Preparation, characterisation, and in vitro enzymatic hydrolysis in biorelevant media Borkar N, Li B, Holm R, Hakansson AE, Mullertz A, Yang M, Mu H European Journal of Pharmaceutics and Biopharmaceutics 2015;89:216-223 - 2015 View abstract
Improve safety monitoring of antipsychotics in the French pediatric population Menard P, Askenazy P, Auby P, Bonnot P, Cohen P Archives de Pediatrie 2015;22(1):92-97 - 2015 View abstract
Evaluation of 309 molecules as inducers of CYP3A4, CYP2B6, CYP1A2, OATP1B1, OCT1, MDR1, MRP2, MRP3 and BCRP in cryopreserved human hepatocytes in sandwich culture Badolo L, Jensen B, Sall C, Norinder U, Kallunki P, Montanari D Xenobiotica 2015;45(2):177-187 - 2015 View abstract
Enhanced inhibitory control by neuropeptide y Y5 receptor blockade in rats Bari M, Dec M, Lee M, Lee M, Song M, Dale M, Peterson M, Zorn M, Huang M, Campbell M, Robbins M, West M Psychopharmacology 2015;232(5):959-973 - 2015 View abstract
Targeting a4ß2 nicotinic acetylcholine receptors in central nervous system disorders: Perspectives on positive allosteric modulation as a therapeutic approach Grupe M, Grunnet M, Bastlund JF, Jensen AA Basic and Clinical Pharmacology and Toxicology 2015;116(3):187-200 - 2015 View abstract
Synthesis and selective functionalization of 1,2,4triazolo-4,3- a pyrazines Demmer CS, Jorgensen M, Kehler J, Bunch L, Rasmussen LK Synlett 2015;26(04):519-524 - 2015 View abstract
Serotonergic Regulation of Prefrontal Cortical Circuitries Involved in Cognitive Processing: A Review of Individual 5-HT Receptor Mechanisms and Concerted Effects of 5-HT Receptors Exemplified by the Multimodal Antidepressant Vortioxetine Leiser SC, Li Y, Pehrson AL, Dale E, Smagin G, Sanchez C ACS chemical neuroscience 2015. E-published March 16, 2015 Vortioxetine 2015 View abstract
Assessment of anti-arrhythmic activity of antipsychotic drugs in an animal model: Influence of non-cardiac a<sub>1</sub>-adrenergic receptors Mow T, Frederiksen K, Thomsen MB European Journal of Pharmacology 2015;748:10-17 Sertindole 2015 View abstract
A double-blind, placebo-controlled comparator study of LY2140023 monohydrate in patients with schizophrenia Downing ACM, Kinon BJ, Millen BA, Zhang L, Liu L, Morozova MA, Brenner R, Rayle TJ, Nisenbaum L, Zhao F, Gomez JC BMC Psychiatry 2014;14(1) Lundbeck 2014
Activation of the mGlu5 receptor for the treatment of schizophrenia and cognitive-deficit-associated disorders Williams T, Jacobson MA, Kalinichev M, Rocher J Topics in Medicinal Chemistry 2014;13:143-182 - 2014 View abstract
Epilepsy-related clinical characteristics and mortality: a systematic review and meta-analysis Neurology 2014;83(21):1968-1977 - 2014 View abstract
The European Union Pediatric legislation: Impact on pharmaceutical research in pediatric populations Auby P Clinical Investigation 2014;4(11):1013-1019 Asenapine 2014 View abstract
Intestinal absorption of the antiepileptic drug substance vigabatrin is altered by infant formula in vitro and in vivo Nohr MK, Thale ZI, Brodin B, Hansen SH, Holm R, Nielsen CU Pharmacology research & perspectives 2014;2(2):e00036 - 2014 View abstract
A randomised, double-blind study in adults with major depressive disorder with an inadequate response to a single course of selective serotonin reuptake inhibitor or serotonin -noradrenaline reuptake inhibitor treatment switched to vortioxetine or agomelatine Montgomery SA, Nielsen RZ, Poulsen LH, Häggström L Human Psychopharmacology 2014;29(5):470-782 Citalopram; Escitalopram; Vortioxetine 2014 View abstract
Patient-specific modeling of the neuroendocrine HPA-axis and its relation to depression: Ultradian and circadian oscillations Gudmand-Hoeyer J, Timmermann S, Ottesen JT Mathematical biosciences 2014;257:23-32 - 2014 View abstract
Evaluation of ring shear testing as a characterization method for powder flow in small-scale powder processing equipment Sogaard SV, Pedersen T, Alleso M, Garnaes J, Rantanen J International journal of pharmaceutics 2014;475(1-2):315-323 - 2014 View abstract
Effects of aripiprazole once-monthly on domains of personal and social performance: Results from 2 multicenter, randomized, double-blind studies Fleischhacker WW, Baker RA, Eramo A, Sanchez R, Tsai LF, Peters-Strickland T, Perry PP, McQuade RD, Johnson BR, Carson WH, Kane JM Schizophrenia research 2014;159(2-3):415-420 Aripiprazole 2014 View abstract
The identification of GPR3 inverse agonist AF64394; The first small molecule inhibitor of GPR3 receptor function Jensen T, Elster L, Nielsen SM, Poda SB, Loechel F, Volbracht C, Klewe IV, David L, Watson SP Bioorganic and Medicinal Chemistry Letters 2014;24(22):5195-5198 - 2014 View abstract
Clobazam is efficacious for patients across the spectrum of disease severity of Lennox-Gastaut syndrome: Post hoc analyses of clinical trial results by baseline seizure-frequency quartiles and VNS experience Wheless JW, Isojarvi J, Lee D, Drummond R, Benbadis SR Epilepsy and behavior 2014;41C:47-52 Clobazam 2014 View abstract
Computational investigation of enthalpy-entropy compensation in complexation of glycoconjugated bile salts with Beta-cyclodextrin and analogs Tidemand KD, Schonbeck C, Holm R, Westh P, Peters GH Journal of physical chemistry. B 2014;118(37):10889-10897 - 2014 View abstract
Regulation of postsynaptic plasticity genes' expression and topography by sustained dopamine perturbation and modulation by acute memantine: Relevance to schizophrenia Iasevoli F, Buonaguro EF, Sarappa C, Marmo F, Latte G, Rossi R, Eramo A, Tomasetti C, de Bartolomeis A Progress in neuro-psychopharmacology and biological psychiatry 2014;54:299-314 Memantine 2014 View abstract
Combining in vitro and in silico methods for better prediction of surfactant effects on the absorption of poorly water soluble drugs-a fenofibrate case example Berthelsen R, Sjogren E, Jacobsen J, Kristensen J, Holm R, Abrahamsson B, Mullertz A International journal of pharmaceutics 2014;473(1-2):356-365 - 2014 View abstract
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